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Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-528281-10MG

CAS Number

[775294-82-1]

Unit

1 x 10 mg

Molecular formula

C24H27ClN2O4

Molecular weight

442,94

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µ,M), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µ,M.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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