Item no.
SAF-526524-5MG
CAS Number
[587852-28-6]
Unit
1 x 5 mg
Molecular formula
C13H13NO3S
Molecular weight
263,31
Shipment details
No Dangerous Good
Back to your search result
Description
A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1&alpha, (68% inhibition of DYRK1&alpha, and Pim-2 at 5 microM), while exhibiting little or no activity against a panel of 57 other kinases (&le,18% inhibition at 5 microM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 microM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20, 50 mg/kg via daily i.p.).
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
Reference Material CoA specimen: for the current lot, please contact your customer service representative at info@labmix24.com
Product data sheet
View all available product details e.g. description, analytes/parameters, CAS Number, concentrations/values, sales unit/product format, method, source, transport information