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PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-521234-1MG

CAS Number

[347155-76-4]

Unit

1 x 1 mg

Shipment details

No Dangerous Good /not restricted

Price on request

Description

A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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