Item no.
SAF-513033-1MG
CAS Number
[194423-15-9]
Unit
1 x 1 mg
Molecular formula
C17H13BrN4O
Molecular weight
369,22
Shipment details
No Dangerous Good /not restricted
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Description
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo., A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
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