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InSolution TAPI-2 - CAS 187034-31-7 - Calbiochem A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 in H?O.

Item no.

SAF-5096120001

Unit

Description

A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-alpha convertase, ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-alpha, IL-6 receptor alpha-subunit, and beta-amyloid precursor protein. Reported to inhibit TNF-alpha release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µ,M).

Structure formula

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid

Analyte	CAS Number	Concentration	Unit	Additional information	Method
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid	[187034-31-7]

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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