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Description

A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µ,M) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µ,M for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µ,M) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells., A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µ,M) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µ,M for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µ,M) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.Please note that the molecular weight for this compound is batch-specific due to variable water content.