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p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem The p53 Activator VII, STIMA-1, also referenced under CAS 91634-12-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Item no.

SAF-506168-25MG

CAS Number

[91634-12-7]

Unit

1 x 25 mg

Molecular formula

C10H8N2O

Molecular weight

172,18

Shipment details

to be checked

Price on request

Description

A cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC50 = 3.4 and 4.9 µ,M, respectively), while exhibiting much reduced potency towards p53-null (IC50 = 9.6, 11.4, and 14.7 µ,M against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC50 = 13.2 and 20.3 µ,M against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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