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p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-506163-5MG

CAS Number

[321351-00-2]

Unit

1 x 5 mg

Molecular formula

C20H16BrClN2O

Molecular weight

415,71

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38alpha and p38beta2 (82% and 93% inhibition with 1 µ,M inhibitor, respectively, IC50 of p38alpha inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38gamma, p38delta, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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