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p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-506153-10MG

CAS Number

[1638-41-1]

Unit

1 x 10 mg

Molecular formula

C12H4Cl6O4S

Molecular weight

456,94

Shipment details

No Dangerous Good /not restricted

Price on request

Description

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38alpha/beta MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (<=23% inhibition at 1 µ,M) against p38gamma/delta, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1beta release from hPBMC (100% vs. 50% inhibition with 100 µ,M respective inhibitor).

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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