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p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Item no.

SAF-506149-1MG

CAS Number

[213261-59-7]

Unit

1 x 1 mg

Molecular formula

C14H12O3S2

Molecular weight

292,37

Price on request

Description

A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53-MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µ,M) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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