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Description

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1, IC50 = 9.5 µ,M). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µ,M) and PRMT6 (IC50 = 118 µ,M). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1., A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1, IC50 = 9.5 µ,M). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µ,M) and PRMT6 (IC50 = 118 µ,M). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.Please note that the molecular weight for this compound is batch-specific due to variable water content.