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Description
A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µ,M). Also shown to block glycine receptors, but with low affinity (Kb = 190 µ,M)., A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (Kb = 190 mM).
Structure formula

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