Item no.
SAF-5058960001
CAS Number
[179386-44-8]
Unit
EA
Shipment details
No Dangerous Good /not restricted
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Description
An extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson's Disease models and to reproduce cocaine's discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
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