Item no.
SAF-5053780001
Unit
EA
Shipment details
No Dangerous Good
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Description
A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IkappaBalpha degradation and NF-kappaB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
Structure formula
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Miscellaneous
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