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Description

A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µ,M) and related kinases including p33cdk2/cyclin A (IC50 = 7 µ,M), p33cdk2/cyclin E (IC50 = 7 µ,M), p33cdk5/p35 (IC50 = 3 µ,M), and p44 MAP kinase (IC50 = 25 µ,M). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 >1 mM), and p40cdk6/cyclin D3 (IC50 >250 µ,M). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µ,l) solution of Olomoucine (Cat. No. 495624) in DMSOis also available., A purine derivative that acts as a potent, reversible, and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µ,M) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µ,M), p33cdk2/cyclin E (IC50 = 7 µ,M), p33cdk5/p35 (IC50 = 3 µ,M), and p44MAPK (IC50 = 25 µ,M). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 >1000 µ,M) and p40cdk6/cyclin D3 (IC50 >250 µ,M). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.