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Description

Contains the nuclear localization sequence (NLS) of the transcription factor NF-kappaB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-kappaB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-kappaB nuclear translocation is maximally inhibited at 18 µ,M., Contains the nuclear localization sequence (NLS) of the transcription factor NF-kappaB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-kappaB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-kappaB nuclear translocation is maximally inhibited at 18 µ,M., NF-kappaB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-kappaB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-kappaB into the nucleus.