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Description

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µ,M. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats., A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µ,l) solution of NF-kappaB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.