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Description

Apoptosis is an essential physiological process that plays a crucial role in normal development and homeostatic mechanisms of multicellular organisms. At least two major apoptotic pathways have been described in mammalian cells: the intrinsic pathway via Caspase-9 activation, in which death arises from mitochondrial dysfunction, and the extrinsic pathway via Caspase-8 activation, in which death is initiated from the activation of cell surface receptors. Bcl-2 family members play an important role in the intrinsic apoptotic pathway and includes over 17 members. Interactions of these Bcl-2 family members function as a &lsquo,life/death switch&rsquo, that integrates diverse inter- and intracellular cues to determine whether or not the stress apoptosis pathway should be activated. For example, Bcl-2 and its closely related anti-apoptotic proteins, Bcl-xL and Mcl-1, can sequester their pro-apoptotic counterparts (BAD, BIM, NOXA and PUMA) and thereby inhibit the initiation steps of apoptosis.The MILLIPLEX(R) MAP 4-plex Bcl-2 Family Apoptosis Panel 4 Magnetic Bead Kit (Cat. No. 48-683MAG) is a premixed kit to be used for the simultaneous quantification of the following 4 analytes:Bcl-xLMcl-1Bcl-2NOXA/Mcl-1