Back to your search result

c-Raf Inhibitor - Calbiochem The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Item no.

SAF-475958-20MG

Unit

1 x 20 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µ,M) and WM3629 (GI50 = 0.86 µ,M) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µ,M, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.

Structure formula

1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Analyte	CAS Number	Concentration	Unit	Additional information	Method
1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Miscellaneous

Certificate of Analysis (specimen)

Reference Material CoA specimen: for the current lot, please contact your customer service representative at info@labmix24.com

Product data sheet

View all available product details e.g. description, analytes/parameters, CAS Number, concentrations/values, sales unit/product format, method, source, transport information