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Description
A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a, Kiapp = 330 nM) by p38alpha in a non-ATP-competitive manner. Does not block the kinase activity of p38alpha towards the other two known p38 substrates, MBP and ATF-2., A non-ATP-competitive, reversible, selective inhibitor of p38alpha-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38alpha-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
Structure formula

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