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Description

Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-kB activation (IC50 = 3 µ,M). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation., A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kappaB activation (IC50 = 3 µ,M). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents beta-secretase cleavage. A 10 mM (1 mg/210 µ,l) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is >=98% pure by HPLC. A material with >=95% purity by HPLC (Cat. No. 474787) is also available.