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NMDAR2C/2D Inhibitor, DQP-1105 - Calbiochem The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

Item no.

SAF-454586-10MG

Unit

1 x 10 mg

Shipment details

No Dangerous Good

Price on request

Description

A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 microM) and GluN1/GluN2D (2.2 microM) over GluN1/GluN2B (206 microM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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