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Description

Full-length recombinant, human MMP-13 fused to a His.Tag sequence and expressed in S. frugiperda insect cells. This 452 amino acid proenzyme contains the N-terminal propeptide, the Ca2+- and Zn2+-binding catalytic domain, the hinge region, and the C-terminal hemopexin domain. Hydrolyzes collagen type II 5 to 6 times faster than collagens Type I and III. Exhibits high activity towards gelatin and degrades alpha1-antichymotrypsin and plasminogen activator inhibitor-2 (PAI-2)., Note: 1 mU = 1 milliunit., Full-length recombinant, human MMP-13 fused to a His.Tag sequence and expressed in S. frugiperda insect cells. This 452 amino acid proenzyme contains an N-terminal propeptide which confers latency to the proenzyme, a Ca2+- and Zn2+- binding catalytic domain, a hinge region, and a C-terminal hemopexin domain. Hydrolyzes collagen type II 5-6 times faster than collagens type I and III. Exhibits high activity towards gelatin and degrades alpha1-antichymotrypsin and plasminogen activator inhibitor-2.