Item no.
SAF-444151-1MG
Unit
1 x 1 mg
Shipment details
No Dangerous Good
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Description
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µ,M for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Structure formula
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Certificate of Analysis (specimen)
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Product data sheet
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