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Description

A furanyl thiazolidinone compound that binds CD11b alphaA/alphaI domain in a reversible manner and stabilizes alphaA in a high-affinity binding conformation toward known CD11b/CD18 (alphaMbeta2, CR3, Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µ,M on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo., A furanyl thiazolidinone compound that binds CD11b alphaA/alphaI domain in a reversible manner and stabilizes alphaA in a high-affinity binding conformation toward known CD11b/CD18 (alphaMbeta2, CR3, Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µ,M on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models in vivo, including thioglycolate-induced peritonitis (10 nmol/0.2 ml/mouse, i.v.), anti-GBM-induced nephritis (25 nmol/0.5 ml/mouse, i.p.), balloon-induced artery injury (50 nmol/1 ml/rat, i.m.), and zebrafish tailfin injury.CR3