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Description

A potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3beta (IC50 = 230 nM), Lck (IC50 = 470 nM), and cyclin-dependent kinases (Cdks). Inhibits Cdk1/cyclin B (IC50 = 400 nM), Cdk2/cyclin A (IC50 = 680 nM), Cdk2/cyclin E (IC50 = 7.5 µ,M), and Cdk5/p25 (IC50 = 850 nM). Also inhibits other kinases such as c-Src (IC50 = 15 µ,M), casein kinase II (IC50 = 20 µ,M), ERK1 (IC50 = 20 µ,M), and ERK2 (IC50 = 9 µ,M). Inhibition is competitive with respect to ATP binding., A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3beta (IC50 = 230 nM), Lck (IC50 = 470 nM), and cyclin-dependent kinases (Cdks). Inhibits Cdk1/cyclin B (IC50 = 400 nM), Cdk2/cyclin A (IC50 = 680 nM), Cdk2/cyclin E (IC50 = 7.5 µ,M), and Cdk5/p25 (IC50 = 850 nM). Also inhibits other kinases such as c-Src (IC50 = 15 µ,M), casein kinase II (IC50 = 20 µ,M), ERK1 (IC50 = 20 µ,M), and ERK2 (IC50 = 9 µ,M). Inhibition is competitive with respect to ATP binding.