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KMO Inhibitor II, JM6 - Calbiochem The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

Item no.

SAF-420361-10MG

Unit

1 x 10 mg

Shipment details

No Dangerous Good

Price on request

Description

An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µ,M) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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