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Description

A cell-permeable 37 amino acid peptide constructed by fusing the JNK binding domain sequence (delta) (amino acids 33-57) of human c-Jun to the HIV-TAT transduction domain sequence (amino acids 47-57) with a gamma-aminobutyric acid (GABA) spacer. Reported to specifically disrupt c-Jun/JNK complex formation and subsequent phosphorylation and activation of c-Jun by JNK in vitro and in intact cells. Also reported to induce apoptosis in HeLa cells. Mode of inhibition is distinct from that of JNK Inhibitor II (SP600125, Cat. No. 420119), so may complement this inhibitor in JNK pathway studies., A cell-permeable 37-mer peptide constructed by fusing human c-Jun delta domain (amino acids 33-57) sequence with that of HIV-TAT protein transduction domain (amino acids 47-57) via a gamma-aminobutyric acid (GABA) spacer. Shown to specifically disrupt c-Jun/JNK complex formation and the subsequent phosphorylation and activation of c-Jun by JNK both in vitro and in intact cells. Since its mode of inhibition is different than that of JNK Inhibitor II (SP600125, Cat. No. 420119), these two inhibitors can complement each other in JNK signaling pathway studies.