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Description

A nonpeptidic thiophenylmethanamine compound that binds interferon-alpha (Kd = 4 µ,M for human IFN-alpha) and prevents IFN-alpha and IFNAR interaction-dependent IFN-alpha production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5 µ,M), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<=4.5 µ,M)., A nonpeptidic thiophenylmethanamine compound that binds interferon-alpha (Kd = 4 µ,M for human IFN-alpha) and prevents IFN-alpha and IFNAR interaction-dependent IFN-alpha production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC50<4.5 µ,M), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µ,M), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<=4.5 µ,M).