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Description

Recombinant, rat insulin degrading enzyme fused to a His.Tag sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides., Recombinant, rat insulin degrading enzyme fused to a His.Tag sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-alpha, and amyloid peptides. Reported to be inversely correlated with brain Abeta peptide levels in insulysin-deficient mice compared to wild-type mice.