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Description

A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µ,M). Inhibits COX-2 at higher concentrations (IC50 = 223 µ,M). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µ,M aspirin = 290 nM). Shown to reduce the total Abeta secretion (Amyloid beta40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) alpha and gamma in both CV-1 and C3H10T1/2 cells (~100 µ,M-500 µ,M)., A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible, competitive, non-selective cyclooxygenase (COX) inhibitor (IC50 = 4.85 µ,M for purified COX-1 and 223 µ,M for purified COX-2). Also reported to inhibit COX-1 and COX-2 activity in intact bovine aortic endothelial cells (BAEC) (IC50 = 7 µ,M for COX-1 and 72.7 µ,M for COX-2). Potently blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µ,M aspirin ~290 nM for ovine COX-1). Decreases the secretion of total Abeta (Amyloid beta40&42) by human neuronal cells and offers neuroprotection against glutamate-, nitric oxide- and superoxide-induced damage. Activates peroxisome proliferator activated receptors alpha and gamma in both CV-1 and C3H10T1/2 cells (~100 µ,M - 500 µ,M).