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Description

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of omega-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation., A major aldehydic product formed by peroxidation of omega-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µ,M)., A major aldehyde product formed by peroxidation of omega-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µ,M). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).