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Description

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µ,M), protein kinase G (Ki = 1.6 µ,M), and myosin light chain kinase (Ki = 3.6 µ,M). Also reported to potently inhibit Rho-associated kinase (ROCK, IC50 = 10.7 µ,M). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency., A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µ,M), protein kinase G (Ki = 1.6 µ,M), and myosin light chain kinase (Ki = 36 µ,M). Also reported to potently inhibit Rho-associated kinase (ROCK, IC50 = 10.7 µ,M). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.