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Description

A cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E beta-cells (by 34% at 10 µ,M) and exhibit good aqueous solubility (199 µ,M in PBS at pH 7.4), as well as chemical and metabolic stability., A cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E beta-cells (by 34% at 10 µ,M) and exhibit good aqueous solubility (199 µ,M in PBS at pH 7.4), as well as chemical (0.1% degradation after 12 days in PBS at 37 C) and metabolic (3% metabolization by human liver S9 stability test) stability.