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Description

A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARalpha agonist (PPARalpha, gamma and delta - EC50 = 6 nM, 1.1 µ,M and 6.2 µ,M for human, 1 nM, 1.3 µ,M and 2.9 µ,M for murine, respectively). Also displays in vivo lipid-lowering activity in rats., A cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonist (EC50 = 6 nM for human PPARalpha, 1.1 µ,M for human PPARgamma, and 6.2 µ,M human PPARdelta, 1 nM for murine PPARalpha, 1.3 µ,M for murine PPARgamma, and 2.9 µ,M murine PPARdelta). Also shown to lower lipid levels in rats.