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Description

A metabolically-stable, competitive inhibitor of protein kinase G type Ialpha and Ibeta (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µ,M). Also reported to block the activation of purified PKA type II (Ki = 10 µ,M). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µ,mol = 2.81 mg., A metabolically-stable, competitive inhibitor of protein kinase G types 1alpha and 1beta (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µ,M) and the activation of purified PKA type II (Ki = 10 µ,M). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µ,mol = 0.56 mg.