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Description

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Ialpha, Ibeta, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µ,mol = 0.61 mg., A potent, cell-permeable inhibitor of protein kinase G Ialpha, Ibeta, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µ,mol = 0.61 mg.