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Description

A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCalpha and PKCbeta, 6 nM for PKCgamma, 10 nM for PKCdelta, 60 nM for PKCzeta). Goe 6983 does not effectively inhibit PKCµ, (IC50 = 20 µ,M) and can thus be used to differentiate PKCµ, from other PKC isozymes., A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCalpha and PKCbeta, 6 nM for PKCgamma, 10 nM for PKCdelta, and 60 nM for PKCzeta). Goe 6983 does not effectively inhibit PKCµ, (IC50 = 20 µ,M) and can thus be used to differentiate PKCµ, from other PKC isozymes.