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Description

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC, IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC alpha-isozyme (IC50 = 2.3 nM) and PKCbetaI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC delta-, epsilon-, and zeta-isozymes even at micromolar levels. Reported to inhibit PKCµ, at higher concentrations (IC50 = 20 nM). A 500 µ,g/ml solution of Goe 6976 (Cat. No. 365253) in anhydrous DMSO is also available., A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC, IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCalpha-isozyme (IC50 = 2.3 nM) and PKCbetaI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC delta-, epsilon-, and zeta-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.