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InSolution GM 6001 - Calbiochem InSolution GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 µl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.

Item no.

SAF-364206-1MG

Unit

1 x 1 mg

Price on request

Description

A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1), Ki = 0.5 nM for gelatinase A (MMP-2), Ki = 27 nM for stromelysin (MMP-3), Ki = 0.1 nM for neutrophil collagenase (MMP-8), and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-alpha in vivo and in vitro and abrogates endotoxin-induced lethality in mice.

Structure formula

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