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Description

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3alpha/beta (IC50 >92 µ,M for Cdk1/cyclin B, >100 µ,M for Cdk5/p25, and GSK-3alpha/beta). Acts as a potent ligand for aryl hydrocarbon receptor (AhR, EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties., A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 >92 µ,M for Cdk1/B, >100 µ,M for Cdk5/p25, and GSK-3alpha/beta). Acts as a potent ligand for aryl hydrocarbon receptor (AhR, EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.