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Description

An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3alpha/beta (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 µ,M, 4.3 µ,M, and 63 µ,M, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 >= 10 µ,M). Yields BIO (Cat. No. 361550) upon hydrolysis., An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3alpha/beta (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µ,M, 4.3 µ,M and 63 µ,M, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 >= 10 µ,M). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 >= 0.1 µ,M) and mammalian (EC50 = 0.16 µ,M) reporter systems.