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Description

A cell-permeable myristoylated form of GSK-3beta Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3beta (IC50 = 40 µ,M). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displays in vivo stability., A cell-permeable myristoylated form of GSK-3beta Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3beta (IC50 = 40 µ,M). Does not affect the activities of Cdc-2, PKB, or PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~ 2.5-fold) in HEK293 cells. Also reported to improve glucose tolerance in diabetic mice. Exhibits greater in vivo stability.