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Description

A cell permeable potent and selective inhibitor of farnesyltransferase (FTase, IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µ,M. Resistant to cleavage by phosphorylation.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water., A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 75 nM). Inhibits geranylgeranyltransferase I (IC50 = 24 µ,M) and II (IC50 = 24 µ,M) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µ,g/ml (25-250 µ,M). Resistant to cleavage by phosphorylation.