Item no.
SAF-343781-100UG
CAS Number
[106375-28-4]
Unit
100 ug
Shipment details
No Dangerous Good /not restricted
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Description
A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µ,M for P2X2/X3 heterooligomeric receptors).
Structure formula
Contents
Miscellaneous
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