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Description

Native factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of ~50 kDa (alpha) and ~38 kDa (beta). Present in normal human serum at about 34 µ,g/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I mediated cleavage of C4b., Native factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (alpha) and 38 kDa (beta). Present in normal human serum at about 34 µ,g/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.