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Description

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents beta-amyloid peptide (Abeta)-induced free radical formation and lipid peroxidation. Imparts protection against Abeta40 and Abeta42 toxicity in hippocampal cultures., A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents beta-amyloid peptide (Abeta)-induced free radical formation and lipid peroxidation and imparts protection against Abeta40 and Abeta42 toxicity in hippocampal cultures.