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Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

Item no.

SAF-324623-5MG

Unit

1 x 5 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µ,M for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µ,M for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit >=10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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