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Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI - CAS 15982-84-0 - Calbiochem The Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI controls the biological activity of Dual Specificity Protein Phosphatase 1/6. Primarily used for Phosphorylation & Dephosphorylation apps.

Item no.

SAF-317496-10MG

Unit

1 x 10 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable cyclohexylamino-indenone compound that acts as an allosteric inhibitor against substrate binding-induced MAPK phosphatase activity of Dusp1/CL100/HVH1/MKP1/PTPN10 and Dusp6/MKP3/PYST1 (57% and 30% reduction, respectively, of 0.21 and 2.1 microg Erk2-induced OMFP dephosphorylation by 0.21 microg Dusp6) by locking Dusp1 and Dusp6 in their low-activity conformation, while exhibiting little activity toward Cdc25B, DUSP3/VHR, DUSP5, or PTP1B. Shown to effectively enhance cellular Erk phosphorylation in HeLa cells overexpressing human Dusp1 and Dusp6 (EC50 = 11.5 and 12.3 microM, respectively). FGF signaling activation by BCI treatment (5 to 10 microM) during zebrafish embryo development is reported to expand myocardial progenitors population at the expense of other progenitor cell types, resulting in enlarged heart size.

Structure formula

(E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one

Analyte	CAS Number	Concentration	Unit	Additional information	Method
(E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one	[15982-84-0]

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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