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Description

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µ,M), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of beta-adrenergic agents., Membrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µ,M for detergent solubilized rat brain membranes, IC50 = 45 µ,M for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µ,M) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of beta-adrenergic agents.